Par Amandine Larrivière, ingénieure agronome responsable de la communication scientifique chez LAPSA.
Publié le 3 décembre 2024

Temps de Lecture 7 min.

LAPSA Anxiété : troubles de comportement, stress et anxiété chez les chiens en élevage

Les chiens, tout comme les humains, peuvent éprouver des troubles du comportement, du stress et de l'anxiété. Ces problèmes sont particulièrement fréquents chez les chiens en élevage en raison des conditions auxquelles ils sont exposés. Comprendre ces troubles est essentiel pour améliorer le bien-être des animaux et assurer leur santé mentale et physique.

Conclusion : Les troubles de comportement, le stress et l’anxiété chez les chiens en élevage sont des problèmes complexes qui nécessitent une approche multidimensionnelle pour être résolus. En améliorant les conditions de vie, en augmentant les opportunités de socialisation et d’exercice, et en fournissant des soins vétérinaires appropriés, il est possible de réduire significativement ces troubles et d’améliorer la qualité de vie des chiens en élevage. Une meilleure compréhension et gestion de ces problèmes sont essentielles pour le bien-être des animaux et le succès des élevages.

Documentation scientifique sur les actifs de LAPSA Anxiété :

Aubépine :

Asher GN, Viera AJ, Weaver MA, Dominik R, Caughey M, Hinderliter AL. Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial.BMC Complement Altern Med. 2012 Mar 29;12:26.

Belz GG, Butzer R, Gaus W, Loew D. Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. Phytomedicine. 2002 Oct;9(7):581-8.

Dalli E, Colomer E, Tormos MC, Cosín-Sales J, Milara J, Esteban E, Sáez G. Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: a randomized, double-blind, placebo-controlled trial. Phytomedicine. 2011 Jun 15;18(8-9):769-75.

Degenring FH, Suter A, Weber M, Saller R. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine. 2003;10(5):363-9.

Erfurt L, Schandry R, Rubenbauer S, Braun U. The effects of repeated administration of camphor-crataegus berry extract combination on blood pressure and on attentional performance - a randomized, placebo-controlled, double-blind study. Phytomedicine. 2014 Sep 25;21(11):1349-55.

Holubarsch CJ, Colucci WS, Meinertz T, Gaus W, Tendera M; Survival and Prognosis: Investigation of Crataegus Extract WS 1442 in CHF (SPICE) trial study group. The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial. Eur J Heart Fail. 2008 Dec;10(12):1255-63.

Niederseer D, Ledl-Kurkowski E, Kvita K, Funk P, Niebauer J, SAFETY AND EFFECTS OF CRATAEGUS EXTRACT WS 1442 AND NORDIC WALKING ON LIPID PROFILE AND ENDOTHELIAL FUNCTION: A RANDOMIZED, PARTIALLY BLINDED PILOT STUDY IN OVERWEIGHT VOLUNTEERS, Acta Clin Croat. 2019 Dec;58(4):604-614

Rietbrock N, Hamel M, Hempel B, Mitrovic V, Schmidt T, Wolf G, [Actions of standardized extracts of Crataegus berries on exercise tolerance and quality of life in patients with congestive heart failure], Arzneimittelforschung. 2001 Oct;51(10):793-8.

Schandry R, Duschek S. The effect of Camphor-Crataegus berry extract combination on blood pressure and mental functions in chronic hypotension--a randomized placebo controlled double blind design. Phytomedicine. 2008 Nov;15(11):914-22.

Schmidt U, Kuhn U, Ploch M, Hübner WD. Efficacy of the Hawthorn (Crataegus) preparation LI 132 in 78 patients with chronic congestive heart failure defined as NYHA functional class II. Phytomedicine. 1994 Jun;1(1):17-24.www.foodchainid.com

Tauchert M Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure. Am Heart J. 2002 May;143(5):910-5.

Trexler SE, Nguyen E, Gromek SM, Balunas MJ, Baker WL Electrocardiographic effects of hawthorn (Crataegus oxyacantha) in healthy volunteers: A randomized controlled trial. Phytother Res. 2018 Aug;32(8):1642-1646.

Walker AF, Marakis G, Morris AP, Robinson PA. Promising hypotensive effect of hawthorn extract: a randomized double-blind pilot study of mild, essential hypertension. Phytother Res. 2002 Feb;16(1):48-54.

Walker AF, Marakis G, Simpson E, Hope JL, Robinson PA, Hassanein M, Simpson HC. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen Pract. 2006 Jun;56(527):437-43.

Werner NS, Duschek S, Schandry R. D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - a randomized, placebo controlled double blind study. Phytomedicine. 2009 Dec;16(12):1077-82.

Zapfe jun G. Clinical efficacy of crataegus extract WS 1442 in congestive heart failure NYHA class II. Phytomedicine. 2001 Jul;8(4):262-6.

Zick SM, Vautaw BM, Gillespie B, Aaronson KD.Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. Eur J Heart Fail. 2009 Oct;11(10):990-9.

Griffonia :

Emanuele E, Bertona M, Minoretti P, Geroldi D. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress. Neuro Endocrinol Lett. 2010;31(5):663-6.

Magnésium et B6 :

Extrait de la liste compilée par la Commission Européenne, en cours de validation par l'EFSA / Extracted from the European Commission compilation list, under EFSAvalidation

Passiflore :

Akhondzadeh S, Mohammadi MR, Mommeni F. Passiflora incarnata in the treatment of attention-deficit hyperactivity disorder in children and adolescents. Therapy, 2005; 2 (4), 609–614.

Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001(a) Oct;26(5):363-7.

Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. J Clin Pharm Ther. 2001(b) Oct;26(5):369-73.

Aslanargun P, Cuvas O, Dikmen B, Aslan E, Yuksel MU. Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia. J Anesth. 2012 Feb;26(1):39-44.

Azimaraghi O, Yousefshahi F, Khatavi F, Zamani MM, Movafegh A. Both Oral Passiflora Incarnata and Oxazepam Can Reduce Pre-Operative Anxiety in Ambulatory Surgery Patients: A Double-Blind, Placebo-Controlled Study. Asian J Pharm Clin Res. 2017 Aug. 1;10(8):331-4.

Christoffoli MT, Bachesk AB, Farah GJ, Ferreira GZ. Assessment of Passiflora incarnata L for conscious sedation of patients during the extraction of mandibular third molars: a randomized, split-mouth, double-blind, crossover study.Quintessence Int. 2021 Oct 19;52(10):868-878.

Da Cunha RS, Amorim KS, Gercina AC, de Oliveira ACA, Dos Santos Menezes L, Groppo FC, Souza LMA. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2021 Mar;25(3):1579-1586.

Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017 Jan 1;22(1):e95-e101.

Dimpfel W, Dipah G N C, Suliman S. Proof of Effectiveness of PASCOFLAIR® in Subjects Suffering from Examination Anxiety Using Quantitative EEG in Combination with Eye-Tracking (EnkephaloVision). A Double-Blind,Randomized, Placebo Controlled, 2-Armed, Phase IV Study in Parallel Design. Pharmacology & Pharmacy. 2016 Oct;7: 424-442.

Dimpfel W, Koch K, Weiss G. Single Dose Effects of Pascoflair® on Current Source Density (CSD) of Human EEG. Neuroscience & Medicine. 2012 Jun;3:130-140.

Fahami F, Asali Z, Aslani A, Fathizadeh N. A comparative study on the effects of Hypericum Perforatum and passionflower on the menopausal symptoms of women referring to Isfahan city health care centers. Iran J Nurs Midwifery Res. 2010 Fall. 154202-7.

Gibbert J, Kreimendahl F, Lebert J, Rychlik R, Trompetter I. Improvement of Stress Resistance and Quality of Life of Adults with Nervous Restlessness after Treatment with a Passionflower Dry Extract. Complement Med Res. 2017Apr;24:83–89.

Kaviani N, Tavakoli M, Tabanmehr M, Havaei R. The efficacy of passiflora incarnata linnaeus in reducing dental anxiety in patients undergoing periodontal treatment. J Dent (Shiraz). 2013 Jun;14(2):68-72.

Lee J, Jung H-Y, Lee S I, Choi J H, Kim S-G. Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. International Clinical Psychopharmacology. 2019 Jan;35:29-35.

Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg. 2008 Jun;106(6):1728-32.

Ngan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res. 2011 Aug;25(8):1153-9.

Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passionflower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients with Generalized Anxiety Disorder: A Double- Blind Placebo-Controlled Study. Iran J Psychiatry. 2016 Jul. 113191-197.

Rokhtabnak , Ghodraty MR, Kholdebarin A, Khatibi A, Seyed Alizadeh SS, Koleini ZS, Zamani MM, Pournajafian A. Comparing the effect of preoperative administration of melatonin and Passiflora incarnata on postoperative cognitive disorders in adult patients undergoing elective surgery. Anesth Pain Med. 2017 Feb;7(1):e41238.

Schulz H, Jobert M, Hübner WD. The quantitative EEG as a screening instrument to identify sedative effects of single doses of plant extracts in comparison with diazepam. Phytomedicine. 1998 Dec;5(6):449-58.

Valériane :

Andreatini R, Sartori VA, Seabra ML, Leite JR. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytother Res. 2002 Nov;16(7):650-4.

Azizi H, Shojaii A, Hashem-Dabaghian F, Noras M, Boroumand A, Ebadolahzadeh Haghani B, Ghods R. Effects of Valeriana officinalis (Valerian) on tension-type headache: A randomized, placebo-controlled, double-blind clinical trial. Avicenna J Phytomed. 2020 May-Jun;10(3):297-304. PMID: 32523884; PMCID: PMC7256276.

Balderer G, Borbély AA. Effect of valerian on human sleep. Psychopharmacology (Berl). 1985;87(4):406-9.

Behboodi Moghadam Z, Rezaei E, Shirood Gholami R, Kheirkhah M, Haghani H. The effect of Valerian root extract on the severity of pre menstrual syndrome symptoms. J Tradit Complement Med. 2016;6(3):309–315. Published 2016 Jan19. doi:10.1016/j.jtcme.2015.09.001

Coxeter PD, Schluter PJ, Eastwood HL, Nikles CJ, Glasziou PP. Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. Complement Ther Med. 2003 Dec;11(4):215-22.

Cropley M, Cave Z, Ellis J, Middleton RW. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions. Phytother Res. 2002 Feb;16(1):23-7.

Cuellar NG, Ratcliffe SJ. Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? Altern Ther Health Med. 2009.Diaper A, Hindmarch I. A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults. Phytother Res. 2004 Oct;18(10):831-6.

Dominguez RA, Bravo-Valverde RL, Kaplowitz BR, Cott JM. Valerian as a hypnotic for Hispanic patients. Cultur Divers Ethnic Minor Psychol. 2000 Feb;6(1):84-92.

Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 2000 Mar;33(2):47-53.

Dorn M. Wirksamkeit und Verträglichkeit von Baldrian versus Oxazepam bei nichtorganischen und nichtpsychiatrischen Insomnien: Eine randomisierte, doppelblinde, klinische Vergleichsstudie [Efficacy and tolerability of Baldrian versus oxazepam in non-organic and non-psychiatric insomniacs: a randomised, double-blind, clinical, comparative study]. Forsch Komplementarmed Klass Naturheilkd. 2000;7(2):79–84. doi:10.1159/000021314

Farah GJ, Ferreira GZ, Danieletto-Zanna CF, Luppi CR, Jacomacci WP. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study. J Oral Maxillofac Surg. 2019;77(9):1796.e1–1796.e8. doi:10.1016/j.joms.2019.05.003

Gharib M, Samani LN, Panah ZE, Naseri M, Bahrani N, Kiani K. The effect of valeric on anxiety severity in women undergoing hysterosalpingography. Glob J Health Sci. 2015 Apr 2;7(3):358-63.

Glass JR, Sproule BA, Herrmann N, Streiner D, Busto UE. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol. 2003;23(3):260–268. doi:10.1097/01.jcp.0000084033.22282.

Gutierrez S, Ang-Lee MK, Walker DJ, Zacny JP. Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers. Pharmacol Biochem Behav. 2004 May;78(1):57-64.

Hallam KT, Olver JS, McGrath C, Norman TR. Comparative cognitive and psychomotor effects of single doses of Valeriana officianalis and triazolam in healthy volunteers. Hum Psychopharmacol. 2003 Dec;18(8):619-25.

Hassani S, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R,Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P. Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology (Berl). 2015 Mar;232(5):843-50.

Herrera-Arellano A, Luna-Villegas G, Cuevas-Uriostegui ML, Alvarez L, Vargas-Pineda G, Zamilpa-Alvarez A, Tortoriello J. Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia. Planta Med. 2001 Nov;67(8):695-9.

Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SR. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore). 2005 Jul;84(4):197-207.

Jenabi E, Shobeiri F, Hazavehei SMM, Roshanaei G. The effect of Valerian on the severity and frequency of hot flashes: A triple-blind randomized clinical trial. Women Health. 2018 Mar;58(3):297-304.

Koetter U, Schrader E, Käufeler R, Brattström A. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytother Res. 2007 Sep;21(9):847-51.

Kohnen R, Oswald WD. The effects of valerian, propranolol, and their combination on activation, performance, and mood of healthy volunteers under social stress conditions. Pharmacopsychiatry. 1988 Nov;21(6):447-8.

Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry. 1999 Nov;32(6):235-41.

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